We postulated previously that systematic differences in menstrual cycle length and/or variability might be used as indicators of underlying hormonal abnormalities that could help explain the endocrine biology of some breast cancer risk factors. In the present study, we prospectively and retrospectively analyzed menstrual cycle patterns in breast cancer cases and controls in two populations. No significant differences were found. This and previous studies emphasize that contemporary women have a long reproductive experience characterized by uninterrupted, regular menses, which is a condition of maximum ovulation potential and which contributes to estrogen stimulation over time.

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Presented at the Conference “Aromatase: New Perspectives for Breast Cancer,” December 6 to 9, 1981, Key Biscayne, Fla. The work was supported by Grant CA15104 from the National Cancer Institute. Data for portions of this study were provided by the Menstruation and Reproductive History Research Program of the Center for Reproductive Health, 109 Connor Drive, Suite 2104, Chapel Hill, N. C. 27514.

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©1982 American Association for Cancer Research.