Blinded urinary assays for cyclic guanosine 3′:5′-monophosphate (cGMP) and cyclic adenosine 3′:5′-monophosphate (cAMP) were performed on 49 subjects with documented abnormal cervical cytology and 21 control subjects with normal cytology. A significant difference in the mean cGMP:cAMP ratios between the case and control groups was found. A significantly greater proportion of women with cytological abnormalities had a cGMP:cAMP ratio above the 0.2 level (p < 0.001). Cases treated surgically for severe dysplasia or carcinoma in situ of the cervix revealed a significant postsurgical fall in the cGMP:cAMP ratios (p < 0.025). The possibility of utilizing urinary ratios of cyclic nucleotides as an objective index in the detection, monitoring of progression, and therapy of preneoplastic cervical lesions is discussed.

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This work was supported in part by the National Cancer Institute, Grant 1R01 CA-25357-01.

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©1982 American Association for Cancer Research.
1982
Cancer Research, Inc.