The effects of lithocholic acid treatment on strand integrity of DNA was studied in intact cells, cell organelles, isolated nucleoids, and isolated DNA. Single-strand breaks were produced in intact cells, in isolated nuclei, and in nucleoids mixed with lysates of cells treated previously with lithocholic acid. These results suggested that the bile acid either was converted to a reactive metabolite in nuclei or had activated a nuclease which produced the strand breaks.

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This work was supported by a research grant from NIH (CA-29562-02).

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©1982 American Association for Cancer Research.
1982
Cancer Research, Inc.