Fibrosarcomas produced by s.c. injection of 5 µg of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.

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This work was supported by Grants-in-Aid for Cancer Research from the Ministry of Health and Welfare and Ministry of Education, Science and Culture and a grant from the Adult Disease Clinic Memorial Foundation.

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