Cell line (LNPL) was established from a tumor biopsy of a nasopharyngeal “histiocytic” lymphoma composed of large noncleaved B-cells. LNPL expressed immunoglobulin M κ surface immunoglobulin, as did the original tumor. LNPL also expressed la antigen but lacked Epstein-Barr virus nuclear antigen. It exhibited a translocation between chromosomes 8 and 14 which has been described in certain other malignant lymphoproliferative disorders. An autologous T-cell line lacked the translocation between chromosomes 8 and 14. LNPL is being used as an immunogen to produce monoclonal antibodies in our laboratory. Such cell lines may facilitate identification of lymphoma-associated surface antigens.

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Supported by the Veterans Administration, Grant IM 207 of the American Cancer Society, Contract N01-CB-84250-31 of the National Cancer Institute, and NIH Grant PHSHL-07107-05.

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