In recent years, salient advances have taken place in the knowledge of the interaction of diets containing high-fat and certain type of fibers and the production of bile acids potentially relevant in the etiology of colon cancer. Other studies also indicate that a high intake of certain dietary fibers, in spite of high dietary fat, not only leads to an increase in stool bulk, thus diluting carcinogens and promoters in the gut, but also modifies the metabolism of these putative substances. These studies thus suggest that both high intake of total fat and low intake of certain fibers may be necessary for the full expression of risk to colon cancer.
Presented at the Workshop on Fat and Cancer, December 10 to 12, 1979, Bethesda, Md. Supported by USPHS Contracts CP95604 and CP85659, Grants CA12376 and CA17613 from NIH, and Grant CA16382 through the Large Bowel Cancer Program from the National Cancer Institute.