4-(Hydroxymethyl)benzenediazonium tetrafluoroborate was administered as 26 weekly s.c. injections of 50 µg/g body weight to randomly bred Swiss mice. In addition, as a solvent control, sodium tetrafluoroborate was given as 26 weekly s.c. injections at 25 µg/g body weight in 0.9% NaCl solution to another group of mice. The 4-(hydroxymethyl)benzenediazonium tetrofluoroborate treatment induced tumors in the subcutis and skin in incidences of 20 and 12%, respectively; while in the solvent sodium tetrafluoroborate-injected mice, the corresponding tumor incidences were 6 and 0%, respectively. Histopathologically, the tumors were classified as a fibroma, fibrosarcomas, rhabdomyosarcomas, and an angiosarcoma in the subcutis and also as squamous cell papillomas and carcinomas of the skin.

4-(Hydroxymethyl)benzenediazonium ion is an ingredient of the cultivated mushroom of commerce Agaricus bisporus.

1

This study was supported by National Institute of Environmental Health Sciences Contract NO1-CP05629 and was presented in part at the 71st Annual Meeting of the American Association for Cancer Research, San Diego, Calif., May 31, 1980 (1).

This content is only available via PDF.
©1981 American Association for Cancer Research.
1981
Cancer Research, Inc.