We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.

1

This research was supported by Grants CA23096 from the National Cancer Institute and NP-154B from the American Cancer Society and by the United States Department of Energy.

This content is only available via PDF.
©1981 American Association for Cancer Research.
1981
Cancer Research, Inc.