The role of urine as a tumor-enhancing agent in urinary bladder carcinogenesis was investigated by using the heterotopically transplanted rat urinary bladder. Bladders removed from rats initiated with the carcinogen N-butyl-N-(4-hydroxy-butyl)nitrosamine in drinking water for 4 or 10 weeks were heterotransplanted to syngeneic rats. Those heterotopically transplanted bladders receiving repeated instillations of normal rat urine subsequent to transplantation had a higher incidence of carcinoma than did those receiving 0.9% NaCl solution. These results suggest that normal urine may contain tumor promoter(s).

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Supported by USPHS Grant CA 14649 through the National Bladder Cancer Project and Northwestern University Medical School, Department of Pathology Funds.

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©1981 American Association for Cancer Research.
1981
Cancer Research, Inc.