The presence of glutathione was demonstrated histochemically in livers of rats treated with diethylnitrosamine or N-nitrosomorpholine. Glutathione content was markedly elevated in adenosine triphosphatase-deficient, γ-glutamyltranspeptidase-positive hyperplastic cell islands. This finding may partly explain the increased resistance of hyperplastic cells to cytotoxic actions of hepatocarcinogens.

1

This study was supported by Grant De 257/1 from the Deutsche Forschungsgemeinschaft.

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©1980 American Association for Cancer Research.
1980
Cancer Research, Inc.