Abstract
The thermal infusion filtration system was designed to manage malignant effusions and treat metastatic cancers of the intracavitary serosa. Hyperthermia, chemotherapy, and cell and debris filtration were administered by a dynamic fluid flow. Preclinical evaluations of surgical procedure, temperature studies, fluid dynamics, and physiology were carried out in 15 dogs (17.2 to 25.4 kg) with peritoneal perfusion at 41°C and 10 liters/hr flow. Results suggest that the dynamics of flow achieves total intracavitary equilibrium in 7 min. The time essential to elevate animal body mass temperature from ambient to 41° varied as a function of mass. The hyperthermia induced expected nonlethal responses in physiology. The system was determined to be safe for clinical procedure.
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