Recommendations for Future Research in Hyperthermia at the Molecular, Cellular, and Animal Levels¹

Recommendations are made for hyperthermia research to be carried out at the molecular, cellular, and animal levels. Effects of heat alone should be distinguished from effects of heat combined with radiation or chemotherapy. Factors to be considered include tumor cell environment, treatment sequencing, thermal tolerance, cell kinetics, any possible nonthermal effects, and therapeutic gain.