Host resistance to neoplastic growth and invasiveness is recognized to be an important factor in determining the occurrence, the progress, and the eventual outcome of every cancer illness. The factors involved in host resistance are briefly reviewed, and the relationship between these factors and ascorbic acid metabolism is presented in detail. It is shown that many factors involved in host resistance to neoplasia are significantly dependent upon the availability of ascorbate.
This study was supported by research grants from the Secretary of State for Scotland. The Educational Foundation of America. The Foundation for Nutritional Advancement, The Argyll and Clyde Health Board, Scotland, and by private donations to the Linus Pauling Institute of Science and Medicine.