Wounding by incision was a promoting stimulus in mouse skin previously initiated with 7,12-dimethylbenz(a)anthracene. Skin massage elicited a marked proliferative response in skin but was not a promoting stimulus.

Wounding mouse skin, either by multiple scalpel incisions or by stripping with silicon carbide paper, led to a marked induction of ornithine decarboxylase activity. In both instances activity was maximal between 20 and 26 hr after wounding, with a secondary rise at 72 hr. Skin massage did not lead to a detectable increase in ornithine decarboxylase activity over the same time period.


This work was supported by the Australian Research Grants Committee and the Australian Tobacco Research Foundation.

This content is only available via PDF.