Specific binding sites for prolactin (PRL) were present in membrane preparations from 7,12-dimethylbenz(a)- anthracene-induced rat mammary tumors. The specific binding of PRL was time and temperature dependent. A significant negative correlation was noted between administered doses of estrogen and the subsequent binding of PRL to tumor cell membranes. Injections of 10 or 25 µg estradiol benzoate daily for 10 days effectively inhibited mammary tumor growth and significantly reduced specific PRL binding to mammary tumor cell membranes.

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Supported in part by NIH Research Grants CA 10771 from the National Cancer Institute and AM 04784 from the National Institute for Arthritis, Metabolism and Digestive Diseases. Published with the approval of the Michigan Agricultural Experiment Station as Journal Article No. 7491.

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©1976 American Association for Cancer Research.
1976
Cancer Research, Inc.