Adriamycin-specific fluorescence appears slowly in living cells and is localized in nuclei and chromosomes. N-Trifluoroacetyladriamycin-14-valerate, a recently synthesized adriamycin analog, differs from the parent anthracycline in the rapid appearance of its fluorescence in the cytoplasm of living cells and the lack of any fluorescent binding to nuclei and chromosomes.

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This investigation was supported by Grant CA-06516, awarded by the National Cancer Institute, Department of Health, Education and Welfare.

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©1976 American Association for Cancer Research.
1976
Cancer Research, Inc.