The metabolism of both testosterone and dehydroepian-drosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin > 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin < 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5α-dihydrotestosterone and 5α-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C19 steroids by rat mammary adenocarcinomas.

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This work was performed with a grant from the Cancer Research Campaign, Grant SP 1256.

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©1976 American Association for Cancer Research.
1976
Cancer Research, Inc.