International data on the distribution of hormonedependent cancers suggest that they are cancers of affluence. Their occurrence parallels that of bowel cancer fairly closely in population and less closely with regard to individual patient risk. The most plausible hypothesis, although based on extremely incomplete knowledge, is that some components of the Western high-protein, high0fat diet acting in early life make individuals prone to develop these cancers.

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Presented at the Conference on Nutrition in the Causation of Cancer, May 19 to 22, 1975, Key Biscayne, Fla. Supported by Contract NO1 CP 43200 National Cancer Institute.

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