Posthypophysectomy activities, changes of lactate dehydrogenase and malate dehydrogenase isozymes, and the ultrastructure of leukemia cells induced by 7,8,12-trimethylbenz(a)anthracene were studied. Ten days postoperatively, lactate dehydrogenase activity showed about a 60% decrease of preoperative value. Morphologically, a decrease in the quantity of endoplasmic reticulum and a variation in the size of mitochondria in leukemia cells were observed on the sixth day postoperatively, following complete hypophysectomy.

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©1974 American Association for Cancer Research.
1974
Cancer Research, Inc.