Free and membrane-bound polysomes prepared from rat ascites hepatoma cells (AH66) incorporated leucine-14C into α-fetoprotein in vitro. The amount of radioactivity incorporated into antiserum-precipitable α-fetoprotein fraction by membrane-bound polysomes was 20 to 90 times higher than that by free polysomes, indicating that α-fetoprotein is mainly synthesized on membrane-bound polysomes in rat ascites hepatoma cells.

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This work was partly supported by a Grant-in-Aid from the Ministry of Education, Japan.

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©1974 American Association for Cancer Research.
1974
Cancer Research, Inc.