In this paper it is shown that the radioactivity detected in DNA, RNA, proteins, and lipids 1 to 5 hr after N-methyl-N-nitrosourea-1-14C administration is retained in hepatoma cells for long periods of time (at least for 48 hr) while it is rapidly eliminated from liver and spleen cells. A hypothesis is suggested that emphasizes the role of turnover processes in mechanisms responsible for the selective toxicity of alkylating agents and nitrosoureas towards tumor cells.


This work was supported by grants from the Academy of Medical Sciences and Academy of Sciences of the USSR.

This content is only available via PDF.