Total lactate dehydrogenase levels and M-type subunits of this enzyme were greatly increased, compared with normal values, in hyperplastic endometrium. The levels of lactate dehydrogenase in 43 cases of hyperplastic endometrium were similar to those in 3 cases of carcinoma of the endometrium. The findings suggest that a biochemical relationship exists between hyperplasia and carcinoma of endometrium.

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We thank the Irish Cancer Society and the Medical Research Council of Ireland for financial support.

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©1974 American Association for Cancer Research.
1974
Cancer Research, Inc.