Ninety-seven cases of Burkitt's lymphoma (BL) have been confirmed by the American Burkitt's Lymphoma Registry. Clinical and epidemiological features closely resemble those reported for BL in Africa. The organs most frequently involved at the time of diagnosis included small intestine and ovaries. Jaw tumors and bone marrow involvement were also common. Although central nervous system disease was initially apparent in only 11% of the patients, 45% developed central nervous system symptoms during the course of disease. In addition to the clinical presentation, an excellent response to therapy and time-space clustering were two additional features of BL in the American patients that resembled African BL.

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Presented at the International Symposium on Human Tumors Associated with Herpesviruses, March 26 to 28, 1973, Bethesda, Md.

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