Surveys of Hodgkin's disease have indicated an approximately threefold excess risk in first-degree relatives. It is suggested that the familial susceptibility results from a combination of genetic and environmental influences. The experimental identification of causal factors (e.g., oncogenic viruses, immune defects, and genetic markers) may be aided by the investigation of multiple-case families.

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Presented at the International Symposium on Human Tumors Associated with Herpesviruses, March 26 to 28, 1973, Bethesda, Md.

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