Two days after a single intragastric dose of the hepatic carcinogen, 3′-methyl-4-dimethylaminoazobenzene, the principal azoprotein in rat liver cytosol was the relatively basic slow h2-5S azoprotein. The principal species of azoprotein at 2 days was the same as that previously found after azocarcinogen was fed for 2.5 through 11 weeks. Apparently, the same one liver protein serves as the principal protein target of azocarcinogen throughout most of the duration of the liver carcinogenesis.

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Supported in part by NIH Grants CA-05945 and C-5598, Grant E-73 from the American Cancer Society, and an appropriation from the Commonwealth of Pennsylvania.

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