The membrane-active antibiotics amphotericin B and polymyxin B enhanced the action of rifampicin, rifampicin analogs, and tetracycline against macromolecular synthesis and growth of mouse L-cells, human HeLa cells, and KB cells in tissue culture. The specificities of the second agents were maintained in that rifampicin inhibited RNA synthesis and tetracycline inhibited protein synthesis.

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Supported by USPHS Research Grants 1 RO1 AI 10622, AI 06213, and CA-125602-1 and by Training Grant AM 05611 and a grant from the John A. Hartford Foundation, Inc.

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