The membrane-active antibiotics amphotericin B and polymyxin B enhanced the action of rifampicin, rifampicin analogs, and tetracycline against macromolecular synthesis and growth of mouse L-cells, human HeLa cells, and KB cells in tissue culture. The specificities of the second agents were maintained in that rifampicin inhibited RNA synthesis and tetracycline inhibited protein synthesis.


Supported by USPHS Research Grants 1 RO1 AI 10622, AI 06213, and CA-125602-1 and by Training Grant AM 05611 and a grant from the John A. Hartford Foundation, Inc.

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