Purified nuclear and microsomal RNA from rat brain, spleen, kidney, and liver were compared by means of competitive DNA-RNA hybridization. In the experiments described in this report a close similarity in the sequences detected by this technique is noted in the nuclear RNA of kidney, brain, and liver, while a portion of these sequences appear to be missing from the nuclear RNA of spleen. Microsomal RNA from each of the four tissues appears to be qualitatively different.


This work was supported in part by grants from the National Cancer Institute (CA-07175) and the American Cancer Society (E-588G). Portions of the work reported were taken from a thesis submitted by C. T. G. in partial fulfillment of the requirements for the Ph.D. degree in the Graduate School of the University of Wisconsin.

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