Purified nuclear and microsomal RNA from rat brain, spleen, kidney, and liver were compared by means of competitive DNA-RNA hybridization. In the experiments described in this report a close similarity in the sequences detected by this technique is noted in the nuclear RNA of kidney, brain, and liver, while a portion of these sequences appear to be missing from the nuclear RNA of spleen. Microsomal RNA from each of the four tissues appears to be qualitatively different.

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This work was supported in part by grants from the National Cancer Institute (CA-07175) and the American Cancer Society (E-588G). Portions of the work reported were taken from a thesis submitted by C. T. G. in partial fulfillment of the requirements for the Ph.D. degree in the Graduate School of the University of Wisconsin.

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