We report the first case of myeloid leukemia in the rabbit; it occurred in a 13.5-month-old strain IIIep male. Its features are distinct from hereditary lymphosarcoma by cell type, organ involvement, and distribution of tumors. Genetic studies are in progress to identify the gene(s) conferring susceptibility to myeloid leukemia and to determine whether an oncogenic (RNA viral) genome is involved.


This work was supported in part by a grant from the Council for Tobacco Research—U. S. A. and by NIH Research Grants HD-01496 from the National Institute of Child Health and Human Development and RR-00251 from the Division of Research Resources. The Jackson Laboratory is fully accredited by the American Association of Accreditation of Laboratory Animal Care.

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