Electron microscopic studies have revealed early stages of Herpesvirus sylvilagus development in the nuclei of the infected cells. Immature virions are similar in their morphology to known herpesviruses. The development of the naked particles occurs either at nuclear or at preformed cytoplasmic membranes, giving rise to two kinds of mature virions characterized by morphologically different outer coats. Cellular response to the infection is expressed by the appearance of nuclear inclusion bodies and a few lysosomes in the cytoplasm.

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Part of this work was sponsored by the Fogarty International Center and Institute de la Santé et de la Recherche Médicale, and was carried out at the Collège de France, Laboratoire de Médecine Experimentale.

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