An immuoelectrophoretogram of catalase in peripheral blood leukocytes showed a distinctive pattern in patients with inflammatory leukocytosis in contrast to that in patients with myelogenous leukemia. An abnormal catalase-related antigen, α, with anodic migration, coexisted with a normal cathodic or β antigen in the peripheral blood leukocytes of patients with inflammatory diseases. Leukocytes of leukemic individuals, however, showed only the abnormal anodic antigen of catalase. This antigen underwent reversion to normal β pattern during clinical remission. These and other observations suggest that transient configurational changes of leukocytic catalase molecules may occur under certain pathological states.
Supported in part by NIH Grant CA-1030-06, USPHS.