Nucleoside deaminase activity was determined following inoculation of mice with several leukemia viruses. The erythroblastic disorders induced by Friend virus and Rauscher virus were associated with markedly elevated levels of spleen nucleoside deaminase. High enzyme activity was also found in transplantable solid tumors and tissue culture lines derived from Friend virus-induced leukemia. The lymphocytic leukemia resulting from Moloney virus infection did not lead to alterations in the level of nucleoside deaminase. It is suggested that the appearance of nucleoside deaminase activity during Friend virus and Rauscher virus leukemogenesis is a reflection of the erythroid nature of these disorders.

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This study was supported by Research Grant CA 06657 from the NIH.

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