Mice of the C57BL/6 strain were inoculated with two different radiation leukemia viruses, and chronological changes in the alkaline phosphatase levels of the thymus, the spleen, the mesenteric lymph nodes, the liver, and the kidney were measured. The two radiation leukemia viruses used, one of which produces a lymphoma incidence of 80 to 100% after inoculation followed by X-irradiation and the other of which induces lymphatic leukemia in 80 to 100% of the inoculated mice without the need for further exposure to irradiation, were injected directly into one thymus lobe of adult mice, and at predetermined time intervals the alkaline phosphatase levels were measured. Elevation of the alkaline phosphatase activity occurred in the “target” tissue, the thymus, simultaneously or, more likely, prior to the development of the disease. The elevation of the alkaline phosphatase levels in the other tissues studied occurred only after dissemination had started.

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This work was supported by a grant from the Israel Cancer Association.

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