The cross-reactivity between the tumor-specific antigen of ascites mouse mammary Tumor MM102 and that of primary spontaneous mammary carcinomas (p-SMC) was studied with the absorption test of specific antiserum and the transplantation immunity test. Anti-MM102 antiserum produced in the syngeneic host (C3H/He mouse) was completely absorbed by established mammary tumor virus (MTV)-induced cell lines derived from various strains of mice but was not absorbed by p-SMC. C3H/He mice which acquired a heightened resistance against transplantation of MM102 showed a low degree of induced resistance to p-SMC. C3H/He mice immunized with p-SMC acquired a heightened resistance against not only p-SMC but also MM102. These results led to the conclusion that some common tumor-specific transplantation antigen exists for MM102 and p-SMC, although the amount of the common antigen was markedly less in p-SMC than in MM102. No differences between MTV-infected C3H/He mice and MTV-free C3Hf mice were observed in the induction of resistance to MM102. This indicates that the common antigen, the MM antigen, would differ from the so-called MTV-related tumor-specific antigen; it is increased by serial transplantation of p-SMC for more than eight passages or 201 days in the syngeneic host, at which time it can be detected by an absorption test.


This work was supported by research grants from the Ministry of Public Health and Welfare and the Ministry of Education, Japan.

This content is only available via PDF.