The cross-reactivity between the tumor-specific antigen of ascites mouse mammary Tumor MM102 and that of primary spontaneous mammary carcinomas (p-SMC) was studied with the absorption test of specific antiserum and the transplantation immunity test. Anti-MM102 antiserum produced in the syngeneic host (C3H/He mouse) was completely absorbed by established mammary tumor virus (MTV)-induced cell lines derived from various strains of mice but was not absorbed by p-SMC. C3H/He mice which acquired a heightened resistance against transplantation of MM102 showed a low degree of induced resistance to p-SMC. C3H/He mice immunized with p-SMC acquired a heightened resistance against not only p-SMC but also MM102. These results led to the conclusion that some common tumor-specific transplantation antigen exists for MM102 and p-SMC, although the amount of the common antigen was markedly less in p-SMC than in MM102. No differences between MTV-infected C3H/He mice and MTV-free C3Hf mice were observed in the induction of resistance to MM102. This indicates that the common antigen, the MM antigen, would differ from the so-called MTV-related tumor-specific antigen; it is increased by serial transplantation of p-SMC for more than eight passages or 201 days in the syngeneic host, at which time it can be detected by an absorption test.

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This work was supported by research grants from the Ministry of Public Health and Welfare and the Ministry of Education, Japan.

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