Sarcoma 37 cells grew more rapidly in castrated male mice than in controls of the same genotype; however, this effect of castration was dependent on the host genotype. Among inbred YS/Wf mice, tumor weight was increased only in castrated yellow Ay/a males and not in the comparable black a/a males. In contrast, mean tumor weight was increased in both yellow Av y/a and black a/a castrated males of the inbred VY/Wf strain.

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This work was supported by USPHS Grants CA-06927 and RR-05539 from the NIH and by an appropriation from the Commonwealth of Pennsylvania. The research described in this report involved animals maintained in animal care facilities, which are fully accredited by the American Association for Accreditation of Laboratory Animal Care.

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