Over 50% tumor inhibition was achieved by immunizing Sprague-Dawley female rats with small amounts of a carcinogen-protein conjugate prior to a single intragastric feeding of 2-anthrylamine, on the basis of numbers of animals developing persistent, palpable tumors. In addition, immunized rats developed fewer tumors, and induction was delayed.


Supported in part by Research Grants CA-06927 and RR-05539 from the NIH, USPHS, and by an appropriation from the Commonwealth of Pennsylvania.

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