This paper describes the growth and transplantation of an androgen/estrogen-induced, hormone-responsive uterine leiomyosarcoma of the Syrian hamster and of several autonomous variants derived from it. The tumor progresses toward autonomy rapidly. In serial transplantation, short periods (100 to 200 days) of androgen/estrogen treatment favor retention of a typical leiomyosarcoma architectural pattern; long treatment (250 to 350 days) favors progression to a very atypical pattern. Removal of hormone support, following establishment of good transplant growth, favors increased malignancy. Both hormone-responsive primary tumor and autonomous, nonresponsive variants are available in a liquid nitrogen tumor bank.

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This investigation was supported by USPHS Grant CA-04516 from the National Cancer Institute.

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