1,1-Bis(4-fluorophenyl)-2-propynyl N-cyclooctylcarbamate and 1,1-bis(4-fluorophenyl)-2-propynyl N-cycloheptylcarbamate were fed to rats for 3 months, and then all surviving animals were killed for necropsy. With the cyclooctyl compound, 18 of an effective number of 25 rats developed malignant lymphoma; 2 developed malignant lymphoma and colonic adenocarcinoma; and 2 developed ileal adenocarcinoma. The first tumor was found after 55 days. With the cycloheptyl compound, 19 of an effective number of 37 rats developed malignant lymphoma; 1 developed malignant lymphoma and mammary adenocarcinoma; and 2 developed mammary adenocarcinoma. The first tumor was found after 54 days.
Presented in part at the 60th Annual Meeting of the American Association for Cancer Research, San Francisco, Calif., March 23, 1969.