Present chromosome data indicate that, among the transplantable Morris rat hepatomas, only six are diploid (9618A, 9633, 7794A, 7800, 9121, and 9098), and only two (9618A, 9633) have a completely normal karyotype. Two previously diploid hepatomas (9618B, 9611B) have recently undergone transition to an aneuploid state. Despite the difficulty in obtaining adequate chromosome preparations from the slow-growing tumor lines, regular reexamination seems indicated on those being used for metabolic studies.

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This investigation was supported in part by Research Grant USPHS CA-10320 from the National Cancer Institute.

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©1969 American Association for Cancer Research.
1969
Cancer Research, Inc.