The total ribonucleoprotein particles were isolated from normal rat liver, regenerating rat liver (24 and 36 hours after partial hepatectomy), primary liver tumors, and Novikoff hepatoma. The profiles were established by two consecutive centrifugations on linear 5–30% and 30–80% sucrose gradients.

The results show that the profiles of total ribonucleoprotein particles differ from the normal profile in the conditions mentioned above. There is a decrease in the monomer and dimer proportions accompanied by a shift towards a heavier polysome population. It would thus seem that active cell proliferation, whether normal or abnormal, is associated with an alteration of the ribosomal population of the tissue.

1

This work has been supported by grants from the National Cancer Institute of Canada and the Medical Research Council of Canada.

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©1969 American Association for Cancer Research.
1969
Cancer Research, Inc.