Direct membrane fluorescence has been successfully accomplished using fluorescein-labeled human gamma-globulins containing antibodies reactive against antigen(s) on the membrane of Burkitt's lymphoma cells infected with EB virus. The membrane staining is inhibited by unlabeled sera from patients with Burkitt's lymphoma but not by a number of control sera, including three isoantisera from multiply transfused individuals.

1

Supported by the Swedish Cancer Society, NIH Grants CA 04747 and CA 03726, the Jane Coffin Childs Foundation, and the International Agency for Cancer Research.

2

We thank G. and W. Henle for infectious mononucleosis cell lines. J. and J. Nadkarni for Burkitt's lymphoma cell lines, and F. Kourilsky for isoantisera.

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©1969 American Association for Cancer Research.
1969
Cancer Research, Inc.