Hydroxyurea inhibits DNA synthesis and growth of mouse embryonic and kidney cells. It is also an effective inhibitor of polyoma virus synthesis in these cells. Uninfected embryo cells are more sensitive to hydroxyurea than infected ones. Several different parameters of polyoma infection, i.e., DNA synthesis, infectivity, and capsid protein formation are affected similarly by hydroxyurea.


This work was supported by grants from the Swedish Cancer Society, Grant CA-04747 from the National Cancer Institute, USPHS, the Damon Runyon Memorial Fund, and Knut and Alice Wallenbergs Foundation.

This content is only available via PDF.