The fine structure of the human wart virus is compared with that of the Shope rabbit papilloma virus. The distribution of the viral antigens within the human wart, as determined by immunofluorescence, is described and compared with the distribution of the viral antigens in the rabbit papilloma. The distribution of viral particles in the two lesions, as determined by electron microscopy, is also compared.

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This investigation was supported by research Grant No. C-4555 from the National Cancer Institute of the NIH, USPHS.

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