The effects of sex hormones on the development of plasma cell tumors in BALB/c mice were studied. Mice of both sexes were injected i.p. with mineral oil. Plasma cell tumors in female mice exhibited a lower incidence and a longer period of latency than those of male mice. Testosterone administration to female mice strikingly accelerated development of mineral oil-induced plasma cell tumors and the growth of transplanted tumors. Progesterone administration suppressed tumorigenesis and increased the number of i.p. mast cells in these mice. Gonadectomy of males stimulated and gonadectomy of females retarded the development of plasma cell tumors. These results demonstrate extensive influence of plasma cell tumorigenesis by sex hormones.

1

This work was supported by the American Cancer Society, Grant No. P-397.

This content is only available via PDF.
©1967 American Association for Cancer Research.
1967
Cancer Research, Inc.