Screening Data from the Cancer Chemotherapy National Service Center Screening Laboratories. XXXV

Data are reported on 1476 synthetic compounds which were tested in the CCNSC primary screens. Almost all of the compounds were tested in Sarcoma 180, Adenocarcinoma 755, Leukemia 1210, and KB cells in culture; some tests were also carried out in Friend virus leukemia, Lewis lung carcinoma, human sarcoma HS1, Hepatoma 129, Walker 256 (intramuscular), Walker 256 (subcutaneous), and Cloudman melanoma (S91). Data are reported only on compounds which have not demonstrated sufficient activity in these systems to warrant further investigation. The number of test systems in the screening program has recently been reduced; the reasons for the reduction are discussed.