A state of relative resistance against the transplantation of isografts of leukemias induced by the Rauscher virus (RV) was developed in BALB/c and CDF1 mice by pretreatment with X-irradiated tumor cells. In mice pretreated with cells from 1 tumor, significant cross-protection was obtained for all other RV-induced tumors tested and for some tumors induced by Moloney virus, but not for leukemia L1210. Although marginal resistance was observed on a few occasions, the inoculation of infectious RV was not an efficient method of inducing transplantation resistance in BALB/c and CDF1 mice. In CDF1 mice resistance to grafts of RV-induced tumors was accompanied by resistance to challenge with RV and the presence of circulating RV neutralizing antibodies.

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Presented in part at the 55th Annual Meeting, American Association for Cancer Research, Chicago, Illinois, April 9–11, 1964.

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