The transformation of a hamster melanotic melanoma to an amelanotic melanoma is associated with an enhancement in heterologous transplantability and the attainment of the ability to metastasize in the alien host. Heterologous transfer is successfully accomplished with the eye, brain, testicle, muscle, or subcutaneous space utilized as a transplantation site, and metastasis is rapid and widespread.

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Research supported by the Jane Coffin Childs Fund for Medical Research (43), the USPHS, (CA-918), and the American Cancer Society, Inc. (P-336).

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©1966 American Association for Cancer Research.
1966
Cancer Research, Inc.