Utilization of the Taper liver tumor for the detection of antineoplastic compounds was investigated. The sensitivity of this tumor to 10 established cancerostatic agents was evaluated in 2 ways: by use of T/C values, ratio of mean tumor diameter of treated (T) tumors to the mean tumor diameter of control (C) tumors; and the more comprehensive toxicity differential index, the ratio of the mean slope for tumor-bearing mice under drug treatment to the mean slope of comparable animals subjected to restricted feeding.

Both methods showed Cytoxan, 5-fluoro-2-deoxyuridine, and Velban to be the most effective drugs against the Taper liver tumor.

1

This study was supported by Contract No. SA-43-ph-2445 with the Cancer Chemotherapy National Service Center, National Cancer Institute, and the Division of Research Facilities and Resources (General Research Support Grant 1S01-FR05534), USPHS.

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©1966 American Association for Cancer Research.
1966
Cancer Research, Inc.