Using the in vitro cytotoxic index against cells obtained from normal AKR/J mice, a method of predicting and paralleling the in vivo mouse toxicity of tolerant antileukemic, nontolerant antileukemic, tolerant anti-normal tissue, and nontolerant anti-normal tissue sera has been developed. This method offers a good but not perfect correlation between in vitro and in vivo observations.

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This work was supported by Grant E-330 from the American Cancer Society.

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©1966 American Association for Cancer Research.
1966
Cancer Research, Inc.