The effects of sex hormones on the incidence and latency of myeloid leukemia induced by ultracentrifugates were studied in RF mice. Mice treated with estradiol had a lower incidence and a longer latency of myeloid leukemia than mice treated with the injection vehicle (sesame oil) or with testosterone. These results support earlier findings that male mice of the RF strain are more susceptible to leukemia induction by cell-free filtrates or by radiation than are females.


Research sponsored by the U. S. Atomic Energy Commission under contract with the Union Carbide Corporation.

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