The antitumor activity of a series of 4-acyl and α-aminoacetyl analogs of vinblastine is described. Marked differences in activity and toxicity were observed. One of the α-aminoacetyl analogs, vinglycinate, produced therapeutic effects in experimental tumors similar to those observed with vincristine, including 100% “cure” of the P-1534 leukemia, but with a greatly reduced toxicity.

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